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A safe, effective choice

Intra-Operative Radiation Therapy (IORT) is a treatment which allows radiation to be applied to the tissue around the tumor in the operating room itself. It is now a consolidated, well known technique, its efficacy proven by a large number of clinical studies.
The patient is treated immediately after tumor ectomy with a single dose of a few dozen Grays of radiation while still anaesthetized. The emission duration depends on the technology used: from a maximum of 30-40 minutes for technologies with lower penetration levels down to a minimum of 1 minute for methods that use electrons.

Beyond IORT, Intra-Operative Electron Radiation Therapy (IOERT).

Electron IORT (IOERT) is the most complete, effective, fast intra-operative radiation therapy method. Technological developments have allowed the use of miniaturized mobile linear accelerators which are lightweight and easy to handle, allowing patients to be treated quickly, without moving them off the operating table. Used as an alternative and/or addition to conventional external radiation therapy, this technique has obvious clinical, operational, social and economic benefits:

Effective, safe, transportable.
LIAC & NOVAC: a revolution in IORT

Intra-operative radiation therapy is the ideal completion of modern tumor surgery, the fundamental ally for safe, effective treatment.

The LIAC 12, LIAC 10 and NOVAC 11 accelerators, created by Sordina IORT Technologies, are the state of the art in this innovative therapy, developed to respond to the patient’s mental, physical and logistical needs.

With the new LIAC & NOVAC linear accelerators, IORT is now even more affordable and financially beneficial for the health facilities which decide to adopt it. Just one device covers the needs of several operating rooms, and patients can be treated on an ordinary operating table.

What’s more, innovative applicator sterilization systems, new radiation protection discs, lightweight, effective shields and Monte Carlo software: SIT offers solutions that cover every aspect for those in search of quick, safe operation.

Clinical benefits

The aim when irradiating a tumor is to direct the highest possible dose at the tumor itself while complying with the tolerance limit for the surrounding healthy tissue.
Intra-operative radiation therapy allows:
- irradiation of the tumor bed with a direct view of the cavity
- sparing of the tumor-free structures or particularly sensitive, vulnerable structures
- administration of higher therapy doses
- administration of extremely uniform doses

Since there is no time gap between surgery and radiation therapy, the cancer cells have no opportunity to reproduce, with a sharp reduction in local recurrences.

“Click HERE for the latest update on case statistics, new protocols and new procedures for use for IORT therapy for each category of disease”

The radiobiological effect of a single administration of high-dose IOERT is considered about 1.5-2.5 times greater than that of the same dose fractionated. For example, a dose of 21Gy is equivalent to fractionated therapy of about 52 Gy: this offers the scope for significantly reducing the dose administered to the patient, with a decrease in radiation-derived complications.

The data in the literature and those which emerged from the world congress of the International Society of Intra-Operative Radiotherapy (ISIORT) in Madrid on 10-13 June 2008 recommend the use of IORT for the following diseases:


For other types of cancers, such as gynecological, lung and esophagus cancers, the data show a clear reduction in local recurrences and an improvement in any symptoms.

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